Antibacterial Activity of 3-Substituted Pyrrole-2,5-diones Against Pseudomonas Aeruginosa

Author(s): Eric Lattmann , Simon Dunn , Suwanna Niamsanit , Jintana Sattayasai , Nison Sattayasai .

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 7 , 2007

Become EABM
Become Reviewer

Abstract:

3-Substituted pyrrole-2,5-diones were synthesised from mucohalogen acids and the antibacterial activity was subsequently determined in biological assays. The minimum inhibitory concentration and the minimum bactericidal concentration of 2a were determined for a wide range of microorganisms in the low micromolar range. Protein identification using SDS-PAGE and LC/MS/MS demonstrated a partly degradation of OprF-related proteins giving an insight into the underlying mechanism of these novel antibacterial agents.

Keywords: Halogenated pyrrole, Antibacterial, Pseudomonas aeruginosa, OprF-related protein

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 4
ISSUE: 7
Year: 2007
Page: [513 - 519]
Pages: 7
DOI: 10.2174/157018007781788570
Price: $58