Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Antibacterial Activity of 3-Substituted Pyrrole-2,5-diones Against Pseudomonas Aeruginosa

Author(s): Eric Lattmann, Simon Dunn, Suwanna Niamsanit, Jintana Sattayasai, Nison Sattayasai.

Abstract:

3-Substituted pyrrole-2,5-diones were synthesised from mucohalogen acids and the antibacterial activity was subsequently determined in biological assays. The minimum inhibitory concentration and the minimum bactericidal concentration of 2a were determined for a wide range of microorganisms in the low micromolar range. Protein identification using SDS-PAGE and LC/MS/MS demonstrated a partly degradation of OprF-related proteins giving an insight into the underlying mechanism of these novel antibacterial agents.

Keywords: Halogenated pyrrole, Antibacterial, Pseudomonas aeruginosa, OprF-related protein

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Article Details

VOLUME: 4
ISSUE: 7
Year: 2007
Page: [513 - 519]
Pages: 7
DOI: 10.2174/157018007781788570
Price: $58