Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Twelve Different HI-6 Salts and their Potency to Reactivate Cyclosarin Inhibited AChE In Vitro

Author(s): Kamil Kuca, Kamil Musilek, Petr Stodulka, Jan Marek, Petra Hanusova, Daniel Jun, Martina Hrabinova, Jiri Kassa, Bohuslav Dolezal.

Abstract:

As it is generally known, different anions of pharmaceutical preparations are generally developed to achieve better pharmacological effect through their adsorption phase. In this article, reactivation potency of twelve salts (sulfate, chloride, acetate, bromide, phosphate, mesylate, tartarate, iodide, malonate, salicylate, maleinate, tosylate) of bisquaternary acetylcholinesterase reactivator HI-6 was tested to elucidate that chemically different anions have no effect on the reactivation of nerve agent-inhibited acetylcholinesterase. For this purpose, cyclosarin was taken as the appropriate member of the nerve agent family. It was found that the use of different salts has no effect on the reactivation potency.

Keywords: HI-6, Reactivator, Acetylcholinesterase, Cyclosarine, Nerve agent, Salt, Ion exchange, Antidote, Oxime, Quaternary nitrogen

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Article Details

VOLUME: 4
ISSUE: 7
Year: 2007
Page: [510 - 512]
Pages: 3
DOI: 10.2174/157018007781788462
Price: $58