In Vitro Cytotoxicity Evaluation of Some Substituted Indazole Derivatives

Author(s): El Mostapha Rakib , Bassou Oulemda , Said Abouricha , Latifa Bouissane , Hassan Ait Mouse , Abdelmajid Zyad .

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 7 , 2007

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Abstract:

A new series of 1- and 6-Substituted 1H-indazoles 2-6 were synthesized in moderate yield, through a simple synthetic strategy using 6-nitroindazole as key intermediate. The cytotoxicity of synthetic compounds was evaluated against kidney carcinoma cell line (BSR) and the human larynx carcinoma (Hep). Some of the newly prepared compounds indicated significant inhibitory activity against these cells in vitro.

Keywords: 6-Nitroindazole Derivatives, Cytotoxicity, BSR and Hep cells

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Article Details

VOLUME: 4
ISSUE: 7
Year: 2007
Page: [467 - 470]
Pages: 4
DOI: 10.2174/157018007781788589
Price: $58

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