In Vitro Cytotoxicity Evaluation of Some Substituted Indazole Derivatives

Title: In Vitro Cytotoxicity Evaluation of Some Substituted Indazole Derivatives

Volume: 4 Issue: 7

Author(s): El Mostapha Rakib, Bassou Oulemda, Said Abouricha, Latifa Bouissane, Hassan Ait Mouse and Abdelmajid Zyad

Affiliation:

Keywords: 6-Nitroindazole Derivatives, Cytotoxicity, BSR and Hep cells

Abstract: A new series of 1- and 6-Substituted 1H-indazoles 2-6 were synthesized in moderate yield, through a simple synthetic strategy using 6-nitroindazole as key intermediate. The cytotoxicity of synthetic compounds was evaluated against kidney carcinoma cell line (BSR) and the human larynx carcinoma (Hep). Some of the newly prepared compounds indicated significant inhibitory activity against these cells in vitro.

Cite this article as:

Rakib Mostapha El, Oulemda Bassou, Abouricha Said, Bouissane Latifa, Mouse Ait Hassan and Zyad Abdelmajid, In Vitro Cytotoxicity Evaluation of Some Substituted Indazole Derivatives, Letters in Drug Design & Discovery 2007; 4 (7) . https://dx.doi.org/10.2174/157018007781788589