Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Microwave-Assisted Synthesis of Substituted 2,4-Diarylthiazoles and their Evaluation as Anticancer Agents

Author(s): Romeo Romagnoli, Pier Giovanni Baraldi, Olga Cruz Lopez, Maria Dora Carrion, Carlota Lopez Cara, Delia Preti, Mojgan Aghazadeh Tabrizi, Jan Balzarini.

Abstract:

The microwave-promoted cyclization method has been used for the synthesis of a series of novel substituted 2,4-diarylthiazoles from α-halo ketones and thioamides using ethanol as solvent. This rapid method produces compounds in good yield within one minute in comparison with conventional heating method. The synthesized molecules have been evaluated for their antiproliferative effects against five different cancer cell lines.

Keywords: Microwave, Thiazole, Anticancer agents

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Article Details

VOLUME: 4
ISSUE: 7
Year: 2007
Page: [464 - 466]
Pages: 3
DOI: 10.2174/157018007781788507
Price: $58