Effect of the Metal Center on the Antitumor Activity of the Analogous Dinuclear Spermine Chelates (PdCl2)2(Spermine) and (PtCl2)2(Spermine)

Author(s): Ana S. Soares , Sonia M. Fiuza , M. Joao Goncalves , Luis A.E. Batista de Carvalho , M. Paula M. Marques , Ana M. Urbano .

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 7 , 2007

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Abstract:

The cytotoxic activity of (PdCl2)2(spermine) against a human cancer cell line (HSC-3) was evaluated. The results show an activity higher than that of the analogous Pt(II) chelate and, for 24 h incubations, identical to that of cisplatin. They also suggest a faster intracellular uptake and DNA binding relative to cisplatin.

Keywords: Multinuclear polyamine complexes, Pt(II), Pd(II), Spermine, Cytotoxic Activity, Anticancer potential

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Article Details

VOLUME: 4
ISSUE: 7
Year: 2007
Page: [460 - 463]
Pages: 4
DOI: 10.2174/157018007781788516
Price: $58