Effect of the Metal Center on the Antitumor Activity of the Analogous Dinuclear Spermine Chelates (PdCl2)2(Spermine) and (PtCl2)2(Spermine)
Ana S. Soares,
Sonia M. Fiuza,
M. Joao Goncalves,
Luis A.E. Batista de Carvalho,
M. Paula M. Marques,
Ana M. Urbano.
The cytotoxic activity of (PdCl2)2(spermine) against a human cancer cell line (HSC-3) was evaluated. The results show an activity higher than that of the analogous Pt(II) chelate and, for 24 h incubations, identical to that of cisplatin. They also suggest a faster intracellular uptake and DNA binding relative to cisplatin.
Keywords: Multinuclear polyamine complexes, Pt(II), Pd(II), Spermine, Cytotoxic Activity, Anticancer potential
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