Inflammation & Allergy-Drug Targets

(Formerly Current Drug Targets - Inflammation & Allergy)

Kurt S Zaenker
Institute of Immunology and Experimental Oncology
University Witten/Herdecke
Stockumerstraße 10
Witten, 58448
Germany

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Exhaled Breath Biomarkers in Asthmatic Children

Author(s): Massimo Corradi, Chiara Zinelli and Carlo Caffarelli

Affiliation: Dipartimento dell'Eta Evolutiva,Universita di Parma, Via Gramsci 14, 43100 Parma, Italy.

Keywords: Asthma, exhaled air, exhaled nitric oxide, exhaled temperature, exhaled condensate

Abstract:

Asthma is a chronic inflammatory disease of the airways which affects about 10-25% of children in Western countries. Monitoring of inflammation is considered an important tool in the diagnosis and follow-up of asthma, including assessment of severity and response to treatment. Bronchial biopsy specimens and bronchoalveolar lavage are reliable ways to assess airway inflammation. However, such invasive procedures are not feasible for repetitive measurements. In clinical practice, correlation of symptom scores and measurement of lung function with airway inflammation may be poor. Bronchial hyperresponsiveness to metacholine and induced sputum are time-consuming, difficult to perform before adolescence and can not be measured serially. Therefore, the greatest interest has recently been directed towards alternative approaches to determine markers involved in the inflammatory reaction. In childhood, such approaches must be noninvasive, reproducible and easy to perform. Furthermore, the inflammatory markers should accurately measure not only the degree of inflammation but also changes depending upon treatment or allergen exposure. Recently, the measurements of inflammatory markers in both exhaled breath and condensate have emerged as a possible non invasive method in the assessment of airway inflammation.

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Article Details

VOLUME: 6
ISSUE: 3
Page: [150 - 159]
Pages: 10
DOI: 10.2174/187152807781696437