Abstract
The connective tissue of virtually all human organs harbors huge amounts of resident CD34+ fibrocytes. Recent studies have shown that CD34+ fibrocytes derive from circulating CD14+ monocytes. CD34+ fibrocytes are involved in wound healing, act as antigen presenting cells and secrete a multitude of cytokines. Due to their diverse functions CD34+ fibrocytes play a role in connective tissue diseases, pulmonary fibrosis and tumor associated stromal remodeling. Stromal remodeling precipitated by invasive carcinomas is characterized by a loss of CD34+ expression paralleled by a gain of α-SMA expression in stromal cells resulting in a phenotype change from CD34+ fibrocytes towards α-SMA positive myofibroblasts. This process is very stereotypic and may play an essential role in local tumor invasion and systemic dissemination, since a reduction of antigen presenting CD34+ fibrocytes might constitute a step in escaping the hosts immune control directed against invasive carcinoma cells.
Keywords: CD34, fibrocytes, stroma, myofibroblast
Current Stem Cell Research & Therapy
Title: CD34+ Fibrocytes: Morphology, Histogenesis and Function
Volume: 2 Issue: 3
Author(s): Peter J. Barth and Christina C. Westhoff
Affiliation:
Keywords: CD34, fibrocytes, stroma, myofibroblast
Abstract: The connective tissue of virtually all human organs harbors huge amounts of resident CD34+ fibrocytes. Recent studies have shown that CD34+ fibrocytes derive from circulating CD14+ monocytes. CD34+ fibrocytes are involved in wound healing, act as antigen presenting cells and secrete a multitude of cytokines. Due to their diverse functions CD34+ fibrocytes play a role in connective tissue diseases, pulmonary fibrosis and tumor associated stromal remodeling. Stromal remodeling precipitated by invasive carcinomas is characterized by a loss of CD34+ expression paralleled by a gain of α-SMA expression in stromal cells resulting in a phenotype change from CD34+ fibrocytes towards α-SMA positive myofibroblasts. This process is very stereotypic and may play an essential role in local tumor invasion and systemic dissemination, since a reduction of antigen presenting CD34+ fibrocytes might constitute a step in escaping the hosts immune control directed against invasive carcinoma cells.
Export Options
About this article
Cite this article as:
Barth J. Peter and Westhoff C. Christina, CD34+ Fibrocytes: Morphology, Histogenesis and Function, Current Stem Cell Research & Therapy 2007; 2 (3) . https://dx.doi.org/10.2174/157488807781696249
DOI https://dx.doi.org/10.2174/157488807781696249 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Promise of CAR T-Cell Therapy for the Treatment of Cancer Stem
Cells: A Short Review
Current Stem Cell Research & Therapy Orphan Nuclear Receptors, Excellent Targets of Drug Discovery
Combinatorial Chemistry & High Throughput Screening Visfatin/PBEF and Atherosclerosis-Related Diseases
Current Vascular Pharmacology Neural Stem Cell Transplantation and CNS Diseases
CNS & Neurological Disorders - Drug Targets Tissue Plasminogen Activator Prevents Restoration of Tight Junction Proteins Through Upregulation of Angiopoietin-2
Current Neurovascular Research Transplantation of Genetically Modified Haematopoietic Stem Cells to Induce Antigen-Specific Tolerance as a Cure for Autoimmune Diseases
Current Stem Cell Research & Therapy Mitochondrial-Associated Metabolic Changes and Neurodegeneration in Huntingtons Disease - from Clinical Features to the Bench
Current Drug Targets Combining Bevacizumab with Radiation or Chemoradiation for Solid Tumors: A Review of the Scientific Rationale, and Clinical Trials
Current Angiogenesis (Discontinued) Macrophage Derived Cystatin B/Cathepsin B in HIV Replication and Neuropathogenesis
Current HIV Research Pharmacological Applications of Diphenylamine and Its Derivative as Potent Bioactive Compound: A Review
Current Bioactive Compounds Viral Vectors for Cancer Gene Therapy: Viral Dissemination and Tumor Targeting
Current Gene Therapy Nanomedicine based on Nucleic Acids: Pharmacokinetic and Pharmacodynamic Perspectives
Current Pharmaceutical Biotechnology A Review of <i>Aristolochia indica</i>: Ethnomedicinal Uses, Phytochemistry, Pharmacological and Toxicological Effects
Current Traditional Medicine Neurotoxicity of Engineered Nanoparticles from Metals
CNS & Neurological Disorders - Drug Targets Mechanism of Anti-Tumor Effect by Curcumin in Hematological Malignancies
Current Pharmaceutical Analysis Anti-Thrombotic Properties of Tomato
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Innovative Topical Formulations for Treatment of Dermatitis
Recent Patents on Inflammation & Allergy Drug Discovery Nanotechnology in Therapeutics – Current Technologies and Applications
Current Nanoscience Prospectives of Solid Self-microemulsifying Systems in Novel Drug Delivery
Current Drug Delivery Understanding the Dual Inhibition of COX-2 and Carbonic Anhydrase-II by Celecoxib and CG100649 Using Density Functional Theory Calculations and other Molecular Modelling Approaches
Protein & Peptide Letters