Abstract
The connective tissue of virtually all human organs harbors huge amounts of resident CD34+ fibrocytes. Recent studies have shown that CD34+ fibrocytes derive from circulating CD14+ monocytes. CD34+ fibrocytes are involved in wound healing, act as antigen presenting cells and secrete a multitude of cytokines. Due to their diverse functions CD34+ fibrocytes play a role in connective tissue diseases, pulmonary fibrosis and tumor associated stromal remodeling. Stromal remodeling precipitated by invasive carcinomas is characterized by a loss of CD34+ expression paralleled by a gain of α-SMA expression in stromal cells resulting in a phenotype change from CD34+ fibrocytes towards α-SMA positive myofibroblasts. This process is very stereotypic and may play an essential role in local tumor invasion and systemic dissemination, since a reduction of antigen presenting CD34+ fibrocytes might constitute a step in escaping the hosts immune control directed against invasive carcinoma cells.
Keywords: CD34, fibrocytes, stroma, myofibroblast
Current Stem Cell Research & Therapy
Title: CD34+ Fibrocytes: Morphology, Histogenesis and Function
Volume: 2 Issue: 3
Author(s): Peter J. Barth and Christina C. Westhoff
Affiliation:
Keywords: CD34, fibrocytes, stroma, myofibroblast
Abstract: The connective tissue of virtually all human organs harbors huge amounts of resident CD34+ fibrocytes. Recent studies have shown that CD34+ fibrocytes derive from circulating CD14+ monocytes. CD34+ fibrocytes are involved in wound healing, act as antigen presenting cells and secrete a multitude of cytokines. Due to their diverse functions CD34+ fibrocytes play a role in connective tissue diseases, pulmonary fibrosis and tumor associated stromal remodeling. Stromal remodeling precipitated by invasive carcinomas is characterized by a loss of CD34+ expression paralleled by a gain of α-SMA expression in stromal cells resulting in a phenotype change from CD34+ fibrocytes towards α-SMA positive myofibroblasts. This process is very stereotypic and may play an essential role in local tumor invasion and systemic dissemination, since a reduction of antigen presenting CD34+ fibrocytes might constitute a step in escaping the hosts immune control directed against invasive carcinoma cells.
Export Options
About this article
Cite this article as:
Barth J. Peter and Westhoff C. Christina, CD34+ Fibrocytes: Morphology, Histogenesis and Function, Current Stem Cell Research & Therapy 2007; 2 (3) . https://dx.doi.org/10.2174/157488807781696249
DOI https://dx.doi.org/10.2174/157488807781696249 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Assay and Dermatokinetics of Tetrahydrocurcumin Lipidic Nanostructures Using Reverse Phase-high Performance Liquid Chromatography
Pharmaceutical Nanotechnology Angiotensin-(1-7): Blood, Heart, and Blood Vessels
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Liver Disease in Diabetes Mellitus: Potential Therapeutic Value of Vitamin E-Silybin Phytosomal Complex
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Mechanism-based Combinations with Pim Kinase Inhibitors in Cancer Treatments
Current Pharmaceutical Design The Promise of Dolutegravir: A Novel Second Generation Integrase Strand Transfer Inhibitor
Current Clinical Pharmacology Antiplatelet and Antileukocyte Effects of Cardiovascular,Immunomodulatory and Chemotherapeutic Drugs
Cardiovascular & Hematological Agents in Medicinal Chemistry Immune-Regulatory Mechanisms of Classical and Experimental Multiple Sclerosis Drugs: A Special Focus on Helminth-Derived Treatments
Current Medicinal Chemistry Phytosterols in Physiological Concentrations Target Multidrug Resistant Cancer Cells
Medicinal Chemistry A Functional Proteomic Approach to the Identification and Characterization of Protein Composition in Wheat Leaf
Current Proteomics Editorial [Hot Topic: Genome and Proteome Analyses of Autoimmune Diseases (Executive Editor: G. Neeck)]
Current Pharmaceutical Design Ex Vivo Gene Transfer for Improvement of Transplanted Pancreatic Islet Viability and Function
Current Pharmaceutical Design Intake of Vitamin C, Probiotics, Flavonoids and Nutritional Status in Pregnant Women with Urinary Tract Infection
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Activated Protein C and Acute Kidney Injury: Selective Targeting of PAR-1
Current Drug Targets Improved Anti-Tumor Activity of Novel Highly Bioactive Liposome-Bound TRAIL in Breast Cancer Cells
Recent Patents on Anti-Cancer Drug Discovery Emerging Role of Colloidal Drug Delivery Systems (CDDS) in NSAID Topical Administration
Current Medicinal Chemistry Regulation of UDP Glucuronosyltransferase Genes
Current Drug Metabolism Quinolone-Based Drugs Against Toxoplasma gondii and Plasmodium spp
Current Drug Targets - Infectious Disorders An Overview on Cardiovascular Protective Effects of Catechins
Cardiovascular & Hematological Disorders-Drug Targets The Mechanisms Responsible for Garlic - Drug Interactions and their In Vivo Relevance
Current Drug Metabolism Emerging Concepts on Inhibitors of Indoleamine 2,3-Dioxygenase in Rheumatic Diseases
Current Medicinal Chemistry