Current Stem Cell Research & Therapy

Anthony Atala  
Wake Forest University School of Medicine,
Medical Center Boulevard
Winston Salem, NC 27157
USA

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CD34+ Fibrocytes: Morphology, Histogenesis and Function

Author(s): Peter J. Barth, Christina C. Westhoff.

Abstract:

The connective tissue of virtually all human organs harbors huge amounts of resident CD34+ fibrocytes. Recent studies have shown that CD34+ fibrocytes derive from circulating CD14+ monocytes. CD34+ fibrocytes are involved in wound healing, act as antigen presenting cells and secrete a multitude of cytokines. Due to their diverse functions CD34+ fibrocytes play a role in connective tissue diseases, pulmonary fibrosis and tumor associated stromal remodeling. Stromal remodeling precipitated by invasive carcinomas is characterized by a loss of CD34+ expression paralleled by a gain of α-SMA expression in stromal cells resulting in a phenotype change from CD34+ fibrocytes towards α-SMA positive myofibroblasts. This process is very stereotypic and may play an essential role in local tumor invasion and systemic dissemination, since a reduction of antigen presenting CD34+ fibrocytes might constitute a step in escaping the hosts immune control directed against invasive carcinoma cells.

Keywords: CD34, fibrocytes, stroma, myofibroblast

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Article Details

VOLUME: 2
ISSUE: 3
Year: 2007
Page: [221 - 227]
Pages: 7
DOI: 10.2174/157488807781696249
Price: $58