Contribution of Analytical Microscopies to Human Neurodegenerative Diseases Research (PSP and AD)

Author(s): Carmen Quintana.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 7 , Issue 9 , 2007

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Abstract:

Using analytical microscopies we have observed an increase of Fe2+ iron-induced oxidative stress inside pathological ferritin (Ft). This finding, together with the presence of Ft in myelinated axons associated with oligodendrocyte processes and myelin sheet fraying, suggests that a dysfunction of ferritin (a ferritinopathy) may be the non-specific agingdependent pathogenic event responsible for neurodegenerative disease.

Keywords: Ferritinopathy, neuropathology, alzheimer, analytical microscopies, nanoSIMS

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Article Details

VOLUME: 7
ISSUE: 9
Year: 2007
Page: [961 - 975]
Pages: 15
DOI: 10.2174/138955707781662654
Price: $58