Abstract
Using analytical microscopies we have observed an increase of Fe2+ iron-induced oxidative stress inside pathological ferritin (Ft). This finding, together with the presence of Ft in myelinated axons associated with oligodendrocyte processes and myelin sheet fraying, suggests that a dysfunction of ferritin (a ferritinopathy) may be the non-specific agingdependent pathogenic event responsible for neurodegenerative disease.
Keywords: Ferritinopathy, neuropathology, alzheimer, analytical microscopies, nanoSIMS
Mini-Reviews in Medicinal Chemistry
Title: Contribution of Analytical Microscopies to Human Neurodegenerative Diseases Research (PSP and AD)
Volume: 7 Issue: 9
Author(s): Carmen Quintana
Affiliation:
Keywords: Ferritinopathy, neuropathology, alzheimer, analytical microscopies, nanoSIMS
Abstract: Using analytical microscopies we have observed an increase of Fe2+ iron-induced oxidative stress inside pathological ferritin (Ft). This finding, together with the presence of Ft in myelinated axons associated with oligodendrocyte processes and myelin sheet fraying, suggests that a dysfunction of ferritin (a ferritinopathy) may be the non-specific agingdependent pathogenic event responsible for neurodegenerative disease.
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Cite this article as:
Quintana Carmen, Contribution of Analytical Microscopies to Human Neurodegenerative Diseases Research (PSP and AD), Mini-Reviews in Medicinal Chemistry 2007; 7 (9) . https://dx.doi.org/10.2174/138955707781662654
DOI https://dx.doi.org/10.2174/138955707781662654 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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