Abstract
A series of Schiff bases of menthone has been synthesized using an appropriate synthetic route and characterized using Thin Layer Chromatography and spectral analysis. The synthesized compounds were evaluated for anticonvulsant activity against maximal electro shock (MES) and strychnine induced seizures model in rats. The neurotoxicity and behavioral depressant studies were also carried out using rotorod and tail suspension methods. Results obtained show that, 84% of the compounds afforded significant protection in the MES screen whereas none of them found to be active in strychnine induced seizures. Schiff base with napthyl amine was found to be most active in the series showing activity in the dose of 10 mg/kg in MES test. Majority of the compounds were found to be active in behavioral depressant screening.
Keywords: Schiff base, anticonvulsant activity, menthone, behavioral depressant activity
Central Nervous System Agents in Medicinal Chemistry
Title: Synthesis and Evaluation of Schiff Bases for Anticonvulsant and Behavioral Depressant Properties
Volume: 7 Issue: 3
Author(s): Jainendra S. Jain, Radheshyam S. Srivastava, Navneet Aggarwal and Reema Sinha
Affiliation:
Keywords: Schiff base, anticonvulsant activity, menthone, behavioral depressant activity
Abstract: A series of Schiff bases of menthone has been synthesized using an appropriate synthetic route and characterized using Thin Layer Chromatography and spectral analysis. The synthesized compounds were evaluated for anticonvulsant activity against maximal electro shock (MES) and strychnine induced seizures model in rats. The neurotoxicity and behavioral depressant studies were also carried out using rotorod and tail suspension methods. Results obtained show that, 84% of the compounds afforded significant protection in the MES screen whereas none of them found to be active in strychnine induced seizures. Schiff base with napthyl amine was found to be most active in the series showing activity in the dose of 10 mg/kg in MES test. Majority of the compounds were found to be active in behavioral depressant screening.
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Jain S. Jainendra, Srivastava S. Radheshyam, Aggarwal Navneet and Sinha Reema, Synthesis and Evaluation of Schiff Bases for Anticonvulsant and Behavioral Depressant Properties, Central Nervous System Agents in Medicinal Chemistry 2007; 7 (3) . https://dx.doi.org/10.2174/187152407781669143
DOI https://dx.doi.org/10.2174/187152407781669143 |
Print ISSN 1871-5249 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6166 |
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