Central Nervous System Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Central Nervous System Agents)

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Synthesis and Evaluation of Schiff Bases for Anticonvulsant and Behavioral Depressant Properties

Author(s): Jainendra S. Jain, Radheshyam S. Srivastava, Navneet Aggarwal, Reema Sinha.

Abstract:

A series of Schiff bases of menthone has been synthesized using an appropriate synthetic route and characterized using Thin Layer Chromatography and spectral analysis. The synthesized compounds were evaluated for anticonvulsant activity against maximal electro shock (MES) and strychnine induced seizures model in rats. The neurotoxicity and behavioral depressant studies were also carried out using rotorod and tail suspension methods. Results obtained show that, 84% of the compounds afforded significant protection in the MES screen whereas none of them found to be active in strychnine induced seizures. Schiff base with napthyl amine was found to be most active in the series showing activity in the dose of 10 mg/kg in MES test. Majority of the compounds were found to be active in behavioral depressant screening.

Keywords: Schiff base, anticonvulsant activity, menthone, behavioral depressant activity

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2007
Page: [200 - 204]
Pages: 5
DOI: 10.2174/187152407781669143
Price: $58