Protein & Peptide Letters

Prof. Ben M. Dunn  
Department of Biochemistry and Molecular Biology
University of Florida
College of Medicine
P.O. Box 100245
Gainesville, FL
USA
Email: bdunn@ufl.edu

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Pigment Epithelium-Derived Factor (PEDF) Prevents Advanced Glycation End Products (AGEs)-Elicited Endothelial Nitric Oxide Synthase (eNOS) Reduction Through Its Anti-Oxidative Properties

Author(s): Sho-ichi Yamagishi, Seiji Ueda, Takanori Matsui, Kazuo Nakamura, Tsutomu Imaizumi, Masayoshi Takeuchi and Seiya Okuda

Affiliation: Department of Medicine,Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.

Abstract:

PEDF is an effective inhibitor of angiogenesis in the eye with neuronal differentiating activity. Here, we show that PEDF prevents the AGEs-elicited eNOS reduction through its anti-oxidative properties. Our present study suggests that PEDF may also play a protective role against atherosclerosis.

Keywords: AGEs, eNOS, oxidative stress, PEDF, peroxynitrite

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Article Details

VOLUME: 14
ISSUE: 8
Page: [832 - 835]
Pages: 4
DOI: 10.2174/092986607781483705
Price: $58