Pigment Epithelium-Derived Factor (PEDF) Prevents Advanced Glycation End Products (AGEs)-Elicited Endothelial Nitric Oxide Synthase (eNOS) Reduction Through Its Anti-Oxidative Properties
Sho-ichi Yamagishi, Seiji Ueda, Takanori Matsui, Kazuo Nakamura, Tsutomu Imaizumi, Masayoshi Takeuchi and Seiya Okuda
Affiliation: Department of Medicine,Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
PEDF is an effective inhibitor of angiogenesis in the eye with neuronal differentiating activity. Here, we show that PEDF prevents the AGEs-elicited eNOS reduction through its anti-oxidative properties. Our present study suggests that PEDF may also play a protective role against atherosclerosis.
Keywords: AGEs, eNOS, oxidative stress, PEDF, peroxynitrite
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