Influence of CD80 and CD86 Co-Stimulation in the Modulation of the Activation of Antigen Presenting Cells

Author(s): Manzoor A. Mir, Javed N. Agrewala.

Journal Name: Current Immunology Reviews

Volume 3 , Issue 3 , 2007

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Abstract:

The role of CD80 and CD86 costimulatory molecules is well established in the activation of T cells but not antigen presenting cells. Recently, many reports in literature have demonstrated categorically the influence of CD80 and CD86 in the activation of B cells and dendritic cells. Stimulation via CD80/CD86 in B cells can modulate their proliferation, IgG secretion and expression of pro-apoptotic and anti-apoptotic molecules, nuclear localization of NF-κB p50 subunit, phosphorylation of Rel A (p65) and IκB-alpha and increased oct-2 expression. In case of dendritic cells, it has been shown that signals induced via CD80 and CD86 enhance the production of IL-6 and IFN-γ which in turn, upregulates the expression of the enzyme indolamine 2, 3-dioxygenase that results in tryptophan catabolism and affects T cell proliferation. Interestingly, it has been shown that co-stimulation through CD80 can restrict the survival of lymphomas and can also induce apoptosis in neural stem cells. Consequently, it may be concluded that CD28/CD152-CD80/86 interaction delivers a bi-directional co-stimulation, thereby not only having impact on the function of T cells, but also antigen presenting cells.

Keywords: Co-stimulation, bi-directional signaling, B cells, dendritic cells, CD80, CD86, CD40

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2007
Page: [160 - 169]
Pages: 10
DOI: 10.2174/157339507781483487
Price: $58