Facile Biphasic Deprotection of Aldehyde Dimethylhydrazones with Aqueous Hydrochloric Acid

Author(s): Richard J. Petroski.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 6 , 2007

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Abstract:

Deprotection of aldehyde dimethylhydrazones was accomplished by stirring a biphasic mixture of the aldehyde dimethylhydrazone, 1M hydrochloric acid, and petroleum ether at room temperature for three to seven hours. The method works with α,β-unsaturated- and diene-aldehyde dimethylhydrazones, which are often difficult compounds to deprotect. Isolated yields ranged from 85% to 97%.

Keywords: Aldehyde dimethylhydrazone, deprotection, biphasic, hydrochloric acid

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Article Details

VOLUME: 4
ISSUE: 6
Year: 2007
Page: [452 - 455]
Pages: 4
DOI: 10.2174/157017807781467551
Price: $65

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