Preparation of Orthogonally-Protected 3-Methoxy-4-Phosphonomethyl-LPhenylalanine,a New Reagent for the Synthesis of Phosphotyrosyl Mimetic-Containing Peptides

Author(s): W.J. Choi, S.-U. Kang, T.R. Burke Jr..

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 6 , 2007

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Abstract:

[(4-Hydroxymethyl-2-methoxyphenyl)methyl]phosphonic acid di-tert-butyl ester (8) served as a key intermediate in the stereoselective preparation of N-Fmoc-3-methoxy-4-(di-tert-butyl)phosphonomethyl-L-phenylalanine (5). Reagent 5 may be useful for the solid-phase synthesis of phosphotyrosyl mimetic-containing peptides.

Keywords: Amino acid, asymmetric, chiral auxiliaries, peptides, stereoselective synthesis

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Article Details

VOLUME: 4
ISSUE: 6
Year: 2007
Page: [433 - 439]
Pages: 7
DOI: 10.2174/157017807781467614
Price: $65

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