Microwave and Polymer Assisted Synthesis of a Small Library of α ,β -Unsaturated Methyl Esters via the Wittig Reaction

Author(s): S. Collina, D. Rossi, M. Urbano, A. Carnevale Baraglia, O. Azzolina.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 6 , 2007

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An efficient protocol based on the combination of microwave dielectric heating and PASP synthesis using the Wittig reaction was developed and applied to the preparation of α,β-unsaturated methyl esters, key intermediates of new sigma ligands. The stereochemistry of the products was also investigated showing a high E:Z isomeric ratio.

Keywords: Wittig reaction, MAOS, PASPS, sigma ligands intermediates, E:Z isomeric ratio

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Article Details

Year: 2007
Page: [384 - 387]
Pages: 4
DOI: 10.2174/157017807781467650
Price: $65

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