Insulin Releasing Properties of the Temporin Family of Antimicrobial Peptides

Author(s): Yasser H.A. Abdel-Wahab , Lamin Marenah , Peter R Flatt , J. Michael Conlon .

Journal Name: Protein & Peptide Letters

Volume 14 , Issue 7 , 2007

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Temporin-1Vb, -1Oe, -1DRb, and -1TGb (10-8 - 10-6M) produced significant (p < 0.05) and concentrationdependent stimulatory effects on insulin secretion from clonal rat BRIN-BD11 cells without increased release of lactate dehydrogenase. Temporin-1Va and temporin-1Vc (10-8 - 10-6M) also stimulated insulin-release but were cytotoxic at 10-6M. Temporin-1DRa was without effect. The temporins at 10-7 M had no effect on intracellular calcium concentrations suggesting that they stimulate insulin release via a KATP channel- independent pathway.

Keywords: Amphibian skin, insulin secretion, temporin, cytolysis

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Article Details

Year: 2007
Page: [702 - 707]
Pages: 6
DOI: 10.2174/092986607781483822
Price: $58

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