Preliminary X-Ray Crystallographic Studies of a Lys49-Phospholipase A2 Homologue from Bothrops pirajai Venom Complexed with p-Bromophenacyl Bromide and α-Tocopherol Inhibitors

Author(s): Juliana I. dos Santos, Daniela P. Marchi-Salvador, Carlos A.H. Fernandes, Lucas B. Silveira, Andreimar M. Soares, Marcos R.M. Fontes.

Journal Name: Protein & Peptide Letters

Volume 14 , Issue 7 , 2007

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PrTX-I, a non-catalytic and myotoxic Lys49-PLA2 from Bothrops pirajai venom has been crystallized alone and in complex with bromophenacyl bromide (BPB), α-tocopherol and α-tocopherol acetate inhibitors. These crystals have shown to diffract X-rays between 2.34 and 1.65 Å resolution. All complexes crystals are isomorphous and belong to the space group P21 whereas native PrTX-I crystals belong to the P3121.

Keywords: Crystallization, X-ray crystallography, Lys49-phospholipase A2, Bothrops pirajai venom, myotoxity, pbromophenacyl bromide, p-BPB, α-tocopherol, vitamin E

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Article Details

Year: 2007
Page: [698 - 701]
Pages: 4
DOI: 10.2174/092986607781483796
Price: $65

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