Abstract
Alterations in the composition of the extracellular matrix (ECM) and its abundance are important features of airway fibrosis, which is observed in lung disorders such as asthma, COPD and cystic fibrosis. The ECM was originally thought to only play a passive, structural role by providing a stable framework for the resident airway cells from which they are synthesized. However, there is now increasing evidence that the ECM impacts on the biological activity of smooth muscle cells, fibroblasts, and epithelial cells. Current anti-asthma therapy is only partially effective in preventing matrix deposition in chronic asthma, and does not reverse established fibrosis. Little is known about the signal transduction pathways that mediate ECM effects on airway smooth muscle cells. Importantly, in order for the ECM to influence myocyte phenotype and function, the cell must possess selective receptors (integrins) to induce intracellular signalling pathways. This mini-review explores current knowledge of the role of the ECM and its receptors (integrins) on airway smooth muscle phenotype and function and highlights their possible importance in airway disease. New signalling molecules that may be essential in mediating ECM-integrin interactions will also be discussed as they may prove to be novel targets for developing new therapies for asthma.
Keywords: Airway remodelling, apoptosis, asthma, βig-h3, caveolin, CD151, cell adhesion, collagen, COPD, extracellular matrix
Current Respiratory Medicine Reviews
Title: Effects of Extracellular Matrix and Integrin Interactions on Airway Smooth Muscle Phenotype and Function: It Takes Two to Tango!
Volume: 3 Issue: 3
Author(s): Thai Tran, Reinoud Gosens and Andrew J. Halayko
Affiliation:
Keywords: Airway remodelling, apoptosis, asthma, βig-h3, caveolin, CD151, cell adhesion, collagen, COPD, extracellular matrix
Abstract: Alterations in the composition of the extracellular matrix (ECM) and its abundance are important features of airway fibrosis, which is observed in lung disorders such as asthma, COPD and cystic fibrosis. The ECM was originally thought to only play a passive, structural role by providing a stable framework for the resident airway cells from which they are synthesized. However, there is now increasing evidence that the ECM impacts on the biological activity of smooth muscle cells, fibroblasts, and epithelial cells. Current anti-asthma therapy is only partially effective in preventing matrix deposition in chronic asthma, and does not reverse established fibrosis. Little is known about the signal transduction pathways that mediate ECM effects on airway smooth muscle cells. Importantly, in order for the ECM to influence myocyte phenotype and function, the cell must possess selective receptors (integrins) to induce intracellular signalling pathways. This mini-review explores current knowledge of the role of the ECM and its receptors (integrins) on airway smooth muscle phenotype and function and highlights their possible importance in airway disease. New signalling molecules that may be essential in mediating ECM-integrin interactions will also be discussed as they may prove to be novel targets for developing new therapies for asthma.
Export Options
About this article
Cite this article as:
Thai Tran , Reinoud Gosens and Andrew J. Halayko , Effects of Extracellular Matrix and Integrin Interactions on Airway Smooth Muscle Phenotype and Function: It Takes Two to Tango!, Current Respiratory Medicine Reviews 2007; 3 (3) . https://dx.doi.org/10.2174/157339807781387481
DOI https://dx.doi.org/10.2174/157339807781387481 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Activation of Macrophages: Establishing a Role for Polysaccharides in Drug Delivery Strategies Envisaging Antibacterial Therapy
Current Pharmaceutical Design Knowledge, Attitude, and Behavior in Avoiding Environmental Tobacco Smoke Exposure at Home among Pregnant Women
Current Women`s Health Reviews Imbalance Between Leukotriene Synthesis and Catabolism Contributes to the Pathogenesis of Allergic Diseases
Medicinal Chemistry Biology of the Interleukin-9 Pathway and its Therapeutic Potential for the Treatment of Asthma
Inflammation & Allergy - Drug Targets (Discontinued) In-person vs. eHealth Mindfulness-based Intervention for Adolescents with Chronic Illnesses: A Pilot Randomized Trial
Adolescent Psychiatry Colon as Target for Drug Delivery
Current Drug Therapy New Potential Targets to Modulate Neutrophil Function in Inflammation
Mini-Reviews in Medicinal Chemistry Nutrition in Infancy
Current Pediatric Reviews Can We Delay the Accelerated Lung Aging in COPD? Anti-Aging Molecules and Interventions
Current Drug Targets Anti-inflammatory Effects of Tacrolimus in a Rat Model of Acute Pancreatitis
Medicinal Chemistry Green Synthesis, Characterization and Antimicrobial Activities of Copper Nanoparticles from the Rhizomes Extract of <i>Picrorhiza kurroa</i>
Pharmaceutical Nanotechnology Editorial (Thematic Issue: Nanoinformatics to Organic Synthesis, ADMET Profiling, and Application of Nanomaterials in Medicinal Chemistry, Medicine, and Biotechnology)
Current Topics in Medicinal Chemistry Transforming Growth Factor-Beta: A Potential New Agent for Pleurodesis
Drug Design Reviews - Online (Discontinued) Insights into Oxidative Stress: The Isoprostanes
Current Medicinal Chemistry Effect of Stigmas of Crocus sativus L. (saffron) on Cell Mediated and Humoral Immunity
The Natural Products Journal Cardiovascular Complications in Inflammatory Bowel Disease
Current Drug Targets Vitamin D Biology in Heart Failure: Molecular Mechanisms and Systematic Review
Current Drug Targets Long-term Exposure to Cadmium in Food and Cigarette Smoke, Liver Effects and Hepatocellular Carcinoma
Current Drug Metabolism Therapeutic Use of Heat Shock Protein 70
Recent Patents on DNA & Gene Sequences Targeting Lentiviral Vectors for Cancer Immunotherapy
Current Cancer Therapy Reviews