β-Cyclodextrin as a Catalyst in Organic Synthesis

Author(s): Sheshanath Vishwanath Bhosale, Sidhanath Vishwanath Bhosale.

Journal Name: Mini-Reviews in Organic Chemistry

Volume 4 , Issue 3 , 2007

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Abstract:

This mini-review outlines recent (until the end of 2006) key developments in the use of β-cyclodextrin as a catalyst in organic synthesis. β-cyclodextrin is a water soluble supramolecular catalyst especially useful for transformations such as oxirane ring-opening, aziridine oxidation of alcohols, hydrolysis of phosphate esters and amidation of acids. It has been used for the selective synthesis of 2,6- naphthalene dicarboxylic acid, introduction of protecting groups and for ester cleavage. Interestingly, it has also been used in the aza- Michael addition of amines to conjugated alkenes, in photo-Reimer-Tiemann reactions and as a phase transfer catalyst.

Keywords: β-cyclodextrin, oxidation and reduction, protection and deprotection, phase transfer catalyst, aqueous medium

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2007
Page: [231 - 242]
Pages: 12
DOI: 10.2174/157019307781369922
Price: $58

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