Preparation and Biological Activities of Heteroarotinoids
Retinoic acid analogs containing an aromatic ring fixed between the 5 and 8 positions of retinoic acid, were synthesized by a palladium-catalyzed cross-coupling reaction between boronic acid and an alkenyltriflate or alkenyliodide. The biological activities of the retinoic acid analogs were evaluated.
Keywords: Heteroarotinoid, Boronic acid, Coupling reaction, RAR, RXR
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