Isoform-Selective Regulation of Adenylyl Cyclase by Forskolin Derivatives:Prediction of Selectivity by Computer-Based Analysis
Adenylyl cyclase is a membrane-bound enzyme that catalyzes the conversion of ATP to cAMP upon various hormonal stimulations. Isoform-selectivity among forskolin derivatives that forskolin and its derivatives are a direct activator of adenylyl cyclase, can be predicted mostly by the distribution of the negative electrostatic potential of each derivative.
Keywords: Adenylyl cyclase, Isoform-selectivity, cAMP, Forskolin, Electrostatic potential, First principles calculations
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