Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Anti-HSV-1 Activity of 1,4-dihydro-4-oxoquinoline Ribonucleosides

Author(s): Carla Veronica B. dos S. Canuto, Claudia R. B. Gomes, Isakelly P. Marques, Leticia V. Faro, Fernanda da Costa Santos, Izabel Christina de P. P. Frugulhetti, Thiago M. L. e Souza, Anna C.Cunha, Gilberto A. Romeiro, Vitor F. Ferreira, Maria Cecilia B.V.de Souza.

Abstract:

Oxoquinolineribonucleosides 1a-j were prepared. These substances were screened for antiviral activity on HSV-1 virus infection, assessed by virus yield assay. The chlorosubstituted ribonucleosides 1b and 1g were the best inhibitors of HSV-1 yield with EC50 of 1.5 ± 0.06 μM and 1.7 ± 0.08 μM, respectively. Compound 1b presented the best selectivity index (SI) with an SI value of 1000.

Keywords: Nucleosides, Oxoquinolineribonucleosides, Anti-HSV-1

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Article Details

VOLUME: 4
ISSUE: 6
Year: 2007
Page: [404 - 409]
Pages: 6
DOI: 10.2174/157018007781387818
Price: $58