We describe synthesis of α-methylated analogues of the natural polyamines and their use as tools in unraveling polyamine functions. Experiments with α-methylated spermidine and spermine revealed that the polyamines are exchangeable in supporting cellular growth. Degradation of the analogues by polyamine oxidase disclosed hidden, aldehydeguided stereospecificity of the enzyme.
Keywords: Hypusine, liver regeneration, pancreatitis, polyamine oxidase, spermidine/spermine N1-acetyltransferase, stereospecificity, transgenic
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