α-Methylated Polyamines as Potential Drugs and Experimental Tools in Enzymology

Author(s): Tuomo A. Keinanen , Aki Jarvinen , Anne Uimari , Jouko Vepsalainen , Alex R. Khomutov , Nikolay A. Grigorenko , Mervi T. Hyvonen , Marc Cerrada-Gimenez , Leena Alhonen , Juhani Janne .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 7 , Issue 8 , 2007

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Abstract:

We describe synthesis of α-methylated analogues of the natural polyamines and their use as tools in unraveling polyamine functions. Experiments with α-methylated spermidine and spermine revealed that the polyamines are exchangeable in supporting cellular growth. Degradation of the analogues by polyamine oxidase disclosed hidden, aldehydeguided stereospecificity of the enzyme.

Keywords: Hypusine, liver regeneration, pancreatitis, polyamine oxidase, spermidine/spermine N1-acetyltransferase, stereospecificity, transgenic

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Article Details

VOLUME: 7
ISSUE: 8
Year: 2007
Page: [813 - 820]
Pages: 8
DOI: 10.2174/138955707781387867
Price: $58

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