Abstract
Accumulating evidence indicates that cancer is maintained by cancer stem cells (CSC). The goal of molecular imaging is to detect pathologic biomarkers, which can lead to early recognition of cancer, better therapeutic management, and improved monitoring for recurrence. The main focus of this review is to describe the different classes of tracers, contrast agents and dyers, and their putative application to improve cancer stem cells detection and follow-up. Although the in vivo cancer diagnosis has not significantly changed for the past three decades, however, in the future it might be possible to trace all cancer cells, including the cancer stem cells.
Keywords: Biomarkers, molecular image, cancer, mouse models, cancer stem cells, translational oncology, experimental therapeutics
Mini-Reviews in Medicinal Chemistry
Title: Medical Chemistry to Spy Cancer Stem Cells from Outside the Body
Volume: 7 Issue: 8
Author(s): Michel Herranz and Isidro Sanchez-Garcia
Affiliation:
Keywords: Biomarkers, molecular image, cancer, mouse models, cancer stem cells, translational oncology, experimental therapeutics
Abstract: Accumulating evidence indicates that cancer is maintained by cancer stem cells (CSC). The goal of molecular imaging is to detect pathologic biomarkers, which can lead to early recognition of cancer, better therapeutic management, and improved monitoring for recurrence. The main focus of this review is to describe the different classes of tracers, contrast agents and dyers, and their putative application to improve cancer stem cells detection and follow-up. Although the in vivo cancer diagnosis has not significantly changed for the past three decades, however, in the future it might be possible to trace all cancer cells, including the cancer stem cells.
Export Options
About this article
Cite this article as:
Michel Herranz and Isidro Sanchez-Garcia , Medical Chemistry to Spy Cancer Stem Cells from Outside the Body, Mini-Reviews in Medicinal Chemistry 2007; 7 (8) . https://dx.doi.org/10.2174/138955707781387894
DOI https://dx.doi.org/10.2174/138955707781387894 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Retroviral Protein Transfer: Falling Apart to Make an Impact
Current Gene Therapy ADAM Metalloproteinases as Potential Drug Targets
Current Medicinal Chemistry Aminopeptidases of Malaria Parasites: New Targets for Chemotherapy
Infectious Disorders - Drug Targets Doxsaliform: A Novel N-Mannich Base Prodrug of a Doxorubicin Formaldehyde Conjugate
Letters in Drug Design & Discovery Equilibrative Nucleoside Transporters in Fetal Endothelial Dysfunction in Diabetes Mellitus and Hyperglycaemia
Current Vascular Pharmacology Chemical and Potential Biological Perspectives of Genus Sarcococca (Buxaceae)
The Natural Products Journal Breast Cancer, a Stem Cell Disease
Current Stem Cell Research & Therapy Interplay between Epigenetics & Cancer Metabolism
Current Pharmaceutical Design Analysis of the Molecular Determinants of the Response of Chronic Myelogenous Leukaemia to Tyrosine Kinase Inhibitors
Current Pharmacogenomics Targeted Cancer Therapy: The Next Generation of Cancer Treatment
Current Drug Discovery Technologies Recent Clinical Trials of Cladribine in Hematological Malignancies and Autoimmune Disorders
Reviews on Recent Clinical Trials Cancer Stem Cells in Pediatric Brain Tumors
Current Stem Cell Research & Therapy Role of Alterations in the Apoptotic Machinery in Sensitivity of Cancer Cells to Treatment
Current Pharmaceutical Design Drug Targeting Strategies in Cancer Treatment: An Overview
Mini-Reviews in Medicinal Chemistry IAPs as a Target for Anticancer Therapy
Current Cancer Drug Targets Rational Design of CPP-based Drug Delivery Systems: Considerations from Pharmacokinetics
Current Pharmaceutical Biotechnology FOXO and FOXM1 in Cancer: The FOXO-FOXM1 Axis Shapes the Outcome of Cancer Chemotherapy
Current Drug Targets Restoration of Chemoresistance Mechanism by Novel Drug Therapies in Breast Cancer Cell Lines
Current Drug Therapy Cell Proliferation and Cytotoxicity Assays
Current Pharmaceutical Biotechnology Metallothioneins and Cancer
Current Protein & Peptide Science