Current Nutrition & Food Science

Undurti N. Das  
UND Life Sciences
Shaker Heights
OH 44120


Nutritional Support in Cancer

Author(s): Paola Costelli, Maurizio Muscaritoli, Fabio Penna, Andrea Bonetto, Valerio Giacomo Minero, Zaira Aversa, Silvia Iannuzzi, Gabriella Bonelli, Francesco M. Baccino, Filippo Rossi Fanelli.


The management of cancer patients is frequently complicated by the occurrence of cachexia, a complex syndrome characterized by marked depletion of body weight, associated with profound alterations of both nutritional status and metabolic homeostasis. Progressive wasting of skeletal muscle mass and adipose tissue is a typical feature of cancer cachexia. This syndrome has a large impact on morbidity and mortality, and significantly affects patients quality of life. On this line, understanding the pathogenic mechanisms of cachexia is of crucial importance to define targeted therapeutic strategies. Many studies have addressed the relevance of nutritional interventions in cancer hosts. In particular, it has been shown that malnutrition in cancer patients can be delayed when nutritional supplementation is adopted early in the course of the disease. The preservation of a good nutritional status, in particular when it is achieved concurrently with specific antineoplastic treatment, will prevent or at least delay the onset of overt cachexia, allowing the use of more aggressive therapeutic regimens. This paper will review the relevant literature, focusing on those options that have shown more promising for the clinical practice.

Keywords: cancer-related anorexia, Malignant tumors, metabolism, HDL-cholesterol levels, Lipid-Mobilizing Factor

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Article Details

Year: 2007
Page: [242 - 248]
Pages: 7
DOI: 10.2174/157340107781369198
Price: $58