Microwave Accelerated Multicomponent Synthesis for a Novel Scaffold of Monastrol Analogues

Author(s): Mazaahir Kidwai, Suchi Kukreja, Shewta Rastogi, Kavita Singhal.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 5 , 2007

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Abstract:

A highly efficient and environmentally benign reaction of dimedone with various aldehydes and Narylthioureas to afford monastrol analogues is revealed. The reaction is found to be sensitive towards the steric and electronic effects of the substituents in variable components. A quantitative optimization of catalytic support is also presented.

Keywords: Monastrol, microwaves, multicomponent reactions, electronic and steric effects

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Article Details

VOLUME: 4
ISSUE: 5
Year: 2007
Page: [357 - 361]
Pages: 5
DOI: 10.2174/157017807781212085
Price: $58

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