Eco-Friendly Synthesis and Biological Evaluation of New Quinoline-Based Dialkyl α-Aminophosphonates

Author(s): Ljerka Tusek-Bozic, Marina Juribasic, Marijana Komac, Vesna Cmrecki, Irena Zrinski, Jan Balzarini, Erik De Clercq.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 5 , 2007

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Abstract:

The eco-friendly synthesis and preliminary biological evaluation of new dialkyl 2- and 3-quinoline-substituted α-aminophosphonates have been described. The conventional and microwave-assisted one- and two-steps reactions of the appropriate aromatic aldehyde, amine and dialkyl phosphite, carried out without or in the presence of solvent and catalyst, have been compared and discussed.

Keywords: α-Aminophosphonate, quinoline, dialkyl phosphonate, cytostatic activity, antiviral activity, microwave-assisted reaction

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Article Details

VOLUME: 4
ISSUE: 5
Year: 2007
Page: [332 - 338]
Pages: 7
DOI: 10.2174/157017807781212049
Price: $58