Eco-Friendly Synthesis and Biological Evaluation of New Quinoline-Based Dialkyl α-Aminophosphonates

Title: Eco-Friendly Synthesis and Biological Evaluation of New Quinoline-Based Dialkyl α-Aminophosphonates

Volume: 4 Issue: 5

Author(s): Ljerka Tusek-Bozic, Marina Juribasic, Marijana Komac, Vesna Cmrecki, Irena Zrinski, Jan Balzarini and Erik De Clercq

Affiliation:

Keywords: α-Aminophosphonate, quinoline, dialkyl phosphonate, cytostatic activity, antiviral activity, microwave-assisted reaction

Abstract: The eco-friendly synthesis and preliminary biological evaluation of new dialkyl 2- and 3-quinoline-substituted α-aminophosphonates have been described. The conventional and microwave-assisted one- and two-steps reactions of the appropriate aromatic aldehyde, amine and dialkyl phosphite, carried out without or in the presence of solvent and catalyst, have been compared and discussed.

Cite this article as:

Ljerka Tusek-Bozic , Marina Juribasic , Marijana Komac , Vesna Cmrecki , Irena Zrinski , Jan Balzarini and Erik De Clercq , Eco-Friendly Synthesis and Biological Evaluation of New Quinoline-Based Dialkyl α-Aminophosphonates, Letters in Organic Chemistry 2007; 4 (5) . https://dx.doi.org/10.2174/157017807781212049