A New Synthesis of Benzoazacrown Ethers Through Pd-Catalyzed Intramolecular Cycloamination Reactions

Author(s): Rafik Omar-Amrani, Raphael Schneider, Yves Fort.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 5 , 2007

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Abstract:

A new synthesis of twelve-, fifteen-, and eighteen-membered benzoazacrown ethers using palladium-catalyzed intramolecular amination is reported. Couplings proceeded in good yields using an in situ generated Pd(0) catalyst associated to N,N-bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene (SIPr) as ligand and t-BuONa as the base.

Keywords: Intramolecular aryl amination, Pd(0) catalyst, N-heterocyclic carbene, benzoazacrown ethers

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Article Details

VOLUME: 4
ISSUE: 5
Year: 2007
Page: [322 - 324]
Pages: 3
DOI: 10.2174/157017807781212058
Price: $65

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