A Mild Synthesis of Nitriles by TPPX2-promoted Dehydration of Primary Amides

Author(s): Daniele Vaccari, Paolo Davoli, Maria Bucciarelli, Alberto Spaggiari, Fabio Prati.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 5 , 2007

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An expeditious route to nitriles via dehydration of primary amides using halotriphenoxy phosphonium halides (TPPX2, X = Cl or Br) is described. The reaction proceeds under very mild conditions and allows the preparation of aromatic and aliphatic nitriles in good to excellent yields.

Keywords: Dehydration, dehydrohalogenation, halotriphenoxy phosphonium halides, imidoyl halides, nitriles, phosphonium salts

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Article Details

Year: 2007
Page: [319 - 321]
Pages: 3
DOI: 10.2174/157017807781212157
Price: $65

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