Synthesis of Oxepin-Annulated Quinolone Heterocycles by Ruthenium Catalyzed Enyne Bond Reorganization/Diels-Alder Reaction

Author(s): Krishna C. Majumdar, Pradip Debnath, Srikanta Samanta.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 5 , 2007

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Abstract:

Synthesis of oxepin-annulated quinolone heterocycles by the combination of Claisen rearrangement, the ringclosing metathesis and Diels-Alder reaction is described. The RCM or RCEM proceeded smoothly in the presence of Grubbs first generation catalyst at room temperature under nitrogen atmosphere.

Keywords: Claisen rearrangement, ring-closing metathesis, enyne metathesis, oxepine, oxacine, Diels-Alder reaction, quinolone derivatives

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Article Details

VOLUME: 4
ISSUE: 5
Year: 2007
Page: [309 - 313]
Pages: 5
DOI: 10.2174/157017807781212067
Price: $65

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