Tumor Suppression by DNA Base Excision Repair | BenthamScience

Tumor Suppression by DNA Base Excision Repair

Author(s): G. Frosina, G. Frosina.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 7 , Issue 7 , 2007

Abstract:

Base excision repair (BER) is the main pathway for repair of endogenous DNA damage. It was expected that different tumor types could derive from BER defects but to date this link is elusive. In vitro and molecular epidemiology studies may be used to unravel this issue.

Keywords: DNA base excision repair, molecular epidemiology, oxidative DNA damage, 8-oxoguanine, glycosylase, mutation, in vitro neoplastic transformation, chemotherapy

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Article Details

VOLUME: 7
ISSUE: 7
Year: 2007
Page: [727 - 743]
Pages: 17
DOI: 10.2174/138955707781024544
Price: $58