An Efficient and Facile Synthesis of 2-Amino-5,6,7,8-tetrahydro-4- arylnaphthalene-1,3-dicarbonitrile and 5-Amino-2,3-dihydro-7-aryl-1Hindene- 4,6-dicarbonitrile Via Multicomponent Coupling Reaction Under Solvent-Free Conditions

Author(s): Liangce Rong, Haiying Wang, Xiaoyue Li, Fang Yang, Hao, Yao, Shujiang Tu, Daqing Shi.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 4 , 2007

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An efficient and facile synthesis of 2-amino-5,6,7,8-tetrahydro-4-arylnaphthalene-1,3- dicarbonitrile and 5-amino-2,3-dihydro-7-aryl-1H-indene-4,6-dicarbonitrile via three-component reaction of cyclohexanone or cyclopentanone, aldehydes and malononitrile under solvent-free conditions using grinding method has been developed. The mild reaction conditions, simple protocol, good yields and cleaner reaction make this protocol practical and economically attractive.

Keywords: 2,6-Dicyanoanilines, tetrahydronaphthalene, dihydroindene, solvent-free condition, multicomponent coupling reaction, grinding

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Article Details

Year: 2007
Page: [296 - 299]
Pages: 4
DOI: 10.2174/157017807781024219
Price: $65

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