Novel Naproxen Derivatives: Lewis Acid/Transition-metal Free Synthesis via C-C Bond Forming Reaction

Title: Novel Naproxen Derivatives: Lewis Acid/Transition-metal Free Synthesis via C-C Bond Forming Reaction

Volume: 4 Issue: 4

Author(s): Sarbani Pal, P. Bindu, Pragnyadhar Reddy Venna and P. K. Dubey

Affiliation:

Keywords: Naproxen, acylation, trifluoroacetic anhydride, phosphoric acid

Abstract: Naproxen or 2-(6-methoxy naphthalen-2-yl)propionic acid participated in trifluoroacetic anhydride/ phosphoric acid mediated C-C bond forming reaction in a regioselective fashion when treated with a variety of arene or heteroarene under a solvent-free condition affording novel 1-aryl/heteroaryl substituted 2-(6-methoxy naphthalen-2-yl)propan-1-ones in good yields.

Cite this article as:

Sarbani Pal , P. Bindu , Pragnyadhar Reddy Venna and P. K. Dubey , Novel Naproxen Derivatives: Lewis Acid/Transition-metal Free Synthesis via C-C Bond Forming Reaction, Letters in Organic Chemistry 2007; 4 (4) . https://dx.doi.org/10.2174/157017807781024255