Novel Naproxen Derivatives: Lewis Acid/Transition-metal Free Synthesis via C-C Bond Forming Reaction

Author(s): Sarbani Pal, P. Bindu, Pragnyadhar Reddy Venna, P. K. Dubey.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 4 , 2007

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Abstract:

Naproxen or 2-(6-methoxy naphthalen-2-yl)propionic acid participated in trifluoroacetic anhydride/ phosphoric acid mediated C-C bond forming reaction in a regioselective fashion when treated with a variety of arene or heteroarene under a solvent-free condition affording novel 1-aryl/heteroaryl substituted 2-(6-methoxy naphthalen-2-yl)propan-1-ones in good yields.

Keywords: Naproxen, acylation, trifluoroacetic anhydride, phosphoric acid

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Article Details

VOLUME: 4
ISSUE: 4
Year: 2007
Page: [292 - 295]
Pages: 4
DOI: 10.2174/157017807781024255
Price: $65

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