A Convenient Synthesis of Novel Substituted Isoxazolo[5,4-d]Pyrimidines

Author(s): Sergey B. Aliabiev, Raisa V. Bykova, Dmitri V. Kravchenko, Alexandre V. Ivachtchenko.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 4 , 2007

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Abstract:

In this work, we present a convenient synthetic route to novel substituted derivatives of isoxazolo[5,4-d]pyrimidines. Starting from 5-amino-isoxazole-4-carboxamides, we have obtained a series of 3,6-substituted isoxazolo[5,4-d]pyrimidin-4(5H)-ones via intermolecular cyclization of initial heterocycles with ethyl triethoxyacetate or diethyl oxalate/succinate. We have also synthesized a number of 4-amino substituted isoxazolo[5,4-d]pyrimidines and 4-amino-isoxazolo[5,4-d]pyrimidine-6-carboxamides using a convenient and simple synthetic approach. We demonstrate the usefulness and versatility of the developed strategy, which can be easily adapted to high-throughput combinatorial format, for the synthesis of variously substituted compounds containing this core fragment.

Keywords: Cyclization, heterocycle, isoxazolo[5,4-d]pyrimidine, amines, carboxamides, library

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Article Details

VOLUME: 4
ISSUE: 4
Year: 2007
Page: [273 - 280]
Pages: 8
DOI: 10.2174/157017807781024183
Price: $65

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