A mild and efficient allylic alkylation of indole derivatives has been developed with high regioselectivity and excellent yields. In the presence of 1mol% FeCl3 catalyst, various indole derivatives could react with allylic acetates at room temperature to provide C-3 allylation products. A green synthesis of C-3 allylated indoles was developed employing FeCl3 as catalyst in water.
Keywords: Allylation, FeCl3, indole, Friedel-Crafts alkylation, allylic acetate
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