A Mild and Efficient C-3 Allylic Alkylation of Indoles Catalyzed by FeCl3

Author(s): Zhe Liu, Li Liu, Zahid Shafiq, Dong Wang, Yong-Jun Chen.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 4 , 2007

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Abstract:

A mild and efficient allylic alkylation of indole derivatives has been developed with high regioselectivity and excellent yields. In the presence of 1mol% FeCl3 catalyst, various indole derivatives could react with allylic acetates at room temperature to provide C-3 allylation products. A green synthesis of C-3 allylated indoles was developed employing FeCl3 as catalyst in water.

Keywords: Allylation, FeCl3, indole, Friedel-Crafts alkylation, allylic acetate

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Article Details

VOLUME: 4
ISSUE: 4
Year: 2007
Page: [256 - 260]
Pages: 5
DOI: 10.2174/157017807781024336
Price: $65

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