A rapid and solvent-free synthesis of methyl 2-(N-substituted aminocarbonyl) acetates has been developed using poly (ethylene glycol) (PEG) as a soluble polymeric support and as a protecting group. PEG was first reacted with Meldrums acid to give PEG-bound malonic acid 2 under microwave-irradiation, and then 2 was coupled with series of amines to produce 3, followed by the cleavage from the PEG using KCN in CH3OH to afford N-substituted methyl aminocarbonyl acetates 4. This simple method requires mild reaction conditions and affords moderate to high yields of the desired products with excellent purities.
Keywords: Poly (ethylene glycol), supported reagents, synthesis, N-substituted methyl aminocarbonyl acetates, microwave irradiation, solventless reactions
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