Letters in Organic Chemistry

Gwilherm Evano
Free University of Brussels
Brussels
Belgium

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High-Yielding Aminocarbonylation of 3-Iodo-2-Tropene by Using Amino Acid Esters as N-Nucleophiles

Author(s): Laszlo Horvath, Zoltan Berente, Laszlo Kollar.

Abstract:

3-Iodo-2-tropene, synthesised from the corresponding ketone (tropinone) via its hydrazone, was carbonylated in palladium-catalysed homogeneous aminocarbonylation reactions. The 3-carboxamides containing both the tropene and the aminoacid moieties of biological importance were obtained in chemospecific reactions and isolated in up to 85 % yields.

Keywords: Tropane, amino acid, palladium, carbonylation, homogeneous catalysis

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Article Details

VOLUME: 4
ISSUE: 4
Year: 2007
Page: [236 - 238]
Pages: 3
DOI: 10.2174/157017807781024345
Price: $58