High-Yielding Aminocarbonylation of 3-Iodo-2-Tropene by Using Amino Acid Esters as N-Nucleophiles
3-Iodo-2-tropene, synthesised from the corresponding ketone (tropinone) via its hydrazone, was carbonylated in palladium-catalysed homogeneous aminocarbonylation reactions. The 3-carboxamides containing both the tropene and the aminoacid moieties of biological importance were obtained in chemospecific reactions and isolated in up to 85 % yields.
Keywords: Tropane, amino acid, palladium, carbonylation, homogeneous catalysis
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