Stereoselective Synthesis of the Core of Naturally Occurring Anti-HIV Isolitseane B

Author(s): Paul Bremond, Elodie Girardeau, Yoann Coquerel, Jean Rodriguez.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 4 , 2007

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Abstract:

A key intermediate in the total synthesis of naturally occurring anti-HIV Isolitseane B has been prepared in five steps from propargyl alcohol, featuring a highly selective mono-transacetalization and a stereoselective Pauson-Khand cyclization.

Keywords: Acetal, Pauson-Khand, anti-HIV, total synthesis, natural products

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Article Details

VOLUME: 4
ISSUE: 4
Year: 2007
Page: [232 - 233]
Pages: 2
DOI: 10.2174/157017807781024237
Price: $65

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