Asymmetric Induction in Darzens Condensation by Means of (R)-5,5- Dimethyl-4-Phenyloxazolidin-2-One as an Effective Chiral Auxiliary

Author(s): Abed Badrian, Manouchehr Mamaghani, Khalil Tabatabaeian, Hassan Valizadeh.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 4 , 2007

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(R)-5,5-dimethyl-4-phenyloxazolidin-2-one 1 which is readily available from (R)-phenylglycine, was shown to be an effective chiral auxiliary for asymmetric Darzens reaction. It was employed in a simple and practical approach for the preparation of optically active glycidic esters.

Keywords: Asymmetric induction, Darzens reaction, N-acyl oxazolidin-2-one, chiral auxiliary, glycidic ester, diastereoselectivity

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Article Details

Year: 2007
Page: [228 - 231]
Pages: 4
DOI: 10.2174/157017807781024327
Price: $65

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