Pigment Epithelium-Derived Factor (PEDF) Inhibits Angiotensin IIInduced Smooth Muscle Cell Proliferation Through Its Anti-Oxidative Properties

Author(s): Sho-ichi Yamagishi, Takanori Matsui, Kazuo Nakamura, Tsutomu Imaizumi.

Journal Name: Protein & Peptide Letters

Volume 14 , Issue 6 , 2007

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Abstract:

Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis, suggesting that loss of this factor may be involved in angiogenic eye disease. Here, we show that PEDF inhibits angiotensin II-induced smooth muscle cell proliferation through its anti-oxidative properties. Our present study suggests that PEDF may play a protective role against atherosclerosis.

Keywords: Angiotensin II, atherosclerosis, oxidative stress, PEDF

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Article Details

VOLUME: 14
ISSUE: 6
Year: 2007
Page: [615 - 617]
Pages: 3
DOI: 10.2174/092986607780989976
Price: $58

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