Molecular Interactions of the Mitochondrial Tim12 Translocase Subunit

Author(s): Catherine Baud, Carine de Marcos-Lousa, Kostas Tokatlidis.

Journal Name: Protein & Peptide Letters

Volume 14 , Issue 6 , 2007

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Abstract:

The small Tims are chaperones that facilitate insertion of hydrophobic precursors into the inner mitochondrial membrane. We purified Tim12 and found it forms dimers that bind to Tim9. In this interaction, Tim12 undergoes structural changes that may be important for transport of its substrates in the mitochondrial carrier import pathway.

Keywords: Mitochondria, small Tims, chaperones, protein assembly

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Article Details

VOLUME: 14
ISSUE: 6
Year: 2007
Page: [597 - 600]
Pages: 4
DOI: 10.2174/092986607780990019
Price: $58

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