Molecular Interactions of the Mitochondrial Tim12 Translocase Subunit
Carine de Marcos-Lousa,
The small Tims are chaperones that facilitate insertion of hydrophobic precursors into the inner mitochondrial membrane. We purified Tim12 and found it forms dimers that bind to Tim9. In this interaction, Tim12 undergoes structural changes that may be important for transport of its substrates in the mitochondrial carrier import pathway.
Keywords: Mitochondria, small Tims, chaperones, protein assembly
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