X-Ray Structure of HIV-1 Protease Tethered Dimer Complexed to Ritonavir

Author(s): Amit Das, Dharmaraj Ramachandra Rao, Madhusoodan Vijayacharya Hosur.

Journal Name: Protein & Peptide Letters

Volume 14 , Issue 6 , 2007

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Abstract:

We report here the 2.5Å structure of HIV-1 protease tethered-dimer ritonavir complex. The inhibitor bound in the active site has different conformations in the two orientations. There is only one hydrogen bond between the inhibitor and the enzyme. The conserved flap-water is not found in the present complex.

Keywords: HIV-1 protease, tethered dimmer, inhibitor, X-ray crystallography

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Article Details

VOLUME: 14
ISSUE: 6
Year: 2007
Page: [565 - 568]
Pages: 4
DOI: 10.2174/092986607780989930
Price: $58

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