Interaction Profiling of T-Cell Epitopes with MHC-Class I Molecules

Author(s): Banaja Priyardarshini Dash, Sumanto Mukherjee, V.L. Suhas, Nagasuma Chandra.

Journal Name: Protein & Peptide Letters

Volume 14 , Issue 6 , 2007

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Abstract:

A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We report a structural bioinformatics study of peptide- HLA complexes to derive features that generate recognition specificity, useful for guiding the design process.

Keywords: Epitope prediction, protein-peptide interaction, HLA class-I, vaccine design, structural bioinformatics

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Article Details

VOLUME: 14
ISSUE: 6
Year: 2007
Page: [557 - 564]
Pages: 8
DOI: 10.2174/092986607780989994
Price: $58

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