A key step in rational vaccine development is to understand how antigens are recognized by their receptors. Several crystal structures of MHC/HLA molecules are now available. We report a structural bioinformatics study of peptide- HLA complexes to derive features that generate recognition specificity, useful for guiding the design process.
Keywords: Epitope prediction, protein-peptide interaction, HLA class-I, vaccine design, structural bioinformatics
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