Distribution of Tripeptides in MHC Binding Peptides

Author(s): Sharmila Anishetty, Gautam Pennathur.

Journal Name: Protein & Peptide Letters

Volume 14 , Issue 6 , 2007

Become EABM
Become Reviewer

Abstract:

Major Histocompatibility Complex (MHC) molecules are cell surface glycoproteins that are central to the process of immunity. MHC Class I and II molecules differ in their peptide binding specificity. In this study we have analyzed a non redundant set of MHC binding peptides derived from MHCPEP database, in terms of tripeptides and their positional preference. Results indicate that certain tripeptides have a preference to appear at a particular position for a specific allele. Further, the distribution of rigid tripeptides across all binding sequences was also analyzed and their positions were correlated with anchor residue positions.

Keywords: Tripeptides, MHC peptides, Rigid tripeptides, Positional preference, Nonamers, MHCPEP

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 14
ISSUE: 6
Year: 2007
Page: [552 - 556]
Pages: 5
DOI: 10.2174/092986607780989895
Price: $58

Article Metrics

PDF: 4