Chimeric T Helper-B Cell Peptides Induce Protective Response Against Japanese Encephalitis Virus in Mice

Author(s): S.S. Dewasthaly, G.S. Bhonde, V.Shankarraman, S.M. Biswas, V.M. Ayachit, M.M. Gore.

Journal Name: Protein & Peptide Letters

Volume 14 , Issue 6 , 2007

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Abstract:

Virus neutralizing MAb binding and T helper cell stimulating peptide epitopes from structural and nonstructural proteins of Japanese encephalitis virus were delineated. It was observed that priming by T helper peptides potentiated neutralizing antibody response against JE virus. Immunization with chimeric T helper - B cell peptides could thus protect mice from lethal challenge with JE virus.

Keywords: Japanese encephalitis virus, MAb binding peptides, Neutralising antibodies, Chimeric Th-B cell peptides, immunopotentiation, Peptide vaccine

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Article Details

VOLUME: 14
ISSUE: 6
Year: 2007
Page: [543 - 551]
Pages: 9
DOI: 10.2174/092986607780990028
Price: $58

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